Cyclothialidine, a novel DNA gyrase inhibitor. I. Screening, taxonomy, fermentation and biological activity.
نویسندگان
چکیده
Streptomyces filipinensis NR 0484 produced a new DNA gyrase inhibitor, cyclothialidine. It showed potent activity against DNA gyrases from Escherichia coli and Micrococcus luteus.
منابع مشابه
Discovery of novel DNA gyrase inhibitors by high-throughput virtual screening.
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In the course of our screening program using a bleb-forming assay, a new inhibitor of protein kinase C (PKC) was found in the fermentation of a streptomycete. The inhibitor, RK-286C (4'-demethylamino-4'-hydroxystaurosporine), inhibited the morphological change of K562 cells, a human chronic erythroleukemia cell, induced by phorbol 12,13-dibutylate at the concentration of 3 microM. The same conc...
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عنوان ژورنال:
- The Journal of antibiotics
دوره 47 1 شماره
صفحات -
تاریخ انتشار 1994